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目的 探讨原发性肾上腺恶性淋巴瘤的临床及病理学特点。 方法 分析 2例原发性肾上腺恶性淋巴瘤病例资料 ,并进行组织形态学观察和免疫组织化学检测。 结果 2例患者年龄分别为 45岁及 5 7岁 ,临床上无特异性 ,组织学上瘤细胞呈弥散分布 ,其间可见薄壁小血管 ,瘤细胞多呈圆形或卵圆形 ,胞浆少 ,核深染 ,异形明显 ,可见核分裂像。免疫组化染色LCA、L2 6、CD74 阳性 ,UCHL 1阴性 ,S 10 0蛋白及CK阴性。 2例病人中 1例术后 3个月因明显恶液质体征自动出院 ,1例失访。 结论 原发性肾上腺恶性淋巴瘤是一种罕见的、恶性程度较高的肿瘤 ,诊断依赖于组织病理学及免疫组织化学标记检查
Objective To investigate the clinical and pathological features of primary adrenal malignant lymphoma. Methods Two cases of primary adrenal malignant lymphoma were analyzed, and histomorphological observation and immunohistochemistry were performed. Results The two patients were 45 years old and 57 years old. They were clinically non-specific. The histologically, the tumor cells were diffusely distributed. Small blood vessels were seen between them. The tumor cells were mostly round or oval and had less cytoplasm. Deep staining of the core, obvious shaped, visible mitotic figures. Immunohistochemical staining for LCA, L2 6, CD74 positive, UCHL 1 negative, S 10 0 protein and CK negative. One of the 2 patients was discharged from the hospital 3 months after the operation due to obvious signs of cachexia and 1 was lost to follow-up. Conclusions Primary adrenal malignant lymphoma is a rare, highly malignant tumor. Diagnosis depends on histopathology and immunohistochemistry.