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氢溴酸槟榔硷小白鼠经口ＬＤ_（５０）３１２．０ｍｇ／ｋｇ、大白鼠ＬＤ_（５０）４４２．４ｍｇ／ｋｇ，属中等毒性、蓄积系数Ｋ＝３．２，属中等蓄积。槟榔粉Ａｍｅｓ试验、小白鼠嗜多染红细胞微核试验、小白鼠精子畸形试验、结果均为阴性，手指尖血淋巴细胞微核检出率、人群嚼槟榔与不嚼槟榔差异无显著性（Χ~２＝１．４４，Ｐ＞０．５５），表明该物质无诱变可能，结果没能显示出嚼槟榔与嚼者口腔粘膜下纤维性变的三致毒性直接联系，但不排除多种刺激因素的协同联合作用，或槟榔渣的长期局部机械刺激作用，或卤水（强硷）所致颊粘膜的烧灼作用。本结果否定了槟榔粉对小白鼠的“三致作用”、与国外某些研究者的肯定结论相反。
The arecoline hydrobromide mouse oral LD_ (50) 312.0mg / kg, rats LD_ (50) 442.4mg / kg, is a moderate toxicity, accumulation coefficient K = 3.2, is a medium accumulation. Betel nut powder Ames test, micronucleus test of mouse polychromatic erythrocytes, mouse sperm abnormality test, the results were negative, the detection rate of micronuclei in finger-tip blood lymphocytes was not significantly different from that of chewing betel nut and chewing betel nut ~ 2 = 1.44, P> 0.55), indicating that the material is not mutagenic possible, the results failed to show chewing areca and chewing oral submucosal fibrosis triple toxicity directly linked, but does not rule out a variety of Synergistic effects of stimuli, long-term local mechanical stimulation of betel nut residues, or cauterization of buccal mucosa caused by brine (strong base). The result negates the “synergy effect” of betel nut powder on mice, which is contrary to the positive conclusion of some foreign researchers.