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最近知道头孢菌素类抗生素都有一点二硫龙样的副作用,并逐渐成为议论的话题。日本化疗学会针对这个问题作了三个专题报道。二硫龙(disulfirm,二乙基氨基甲酰二硫酸盐)是众所周知的治疗慢性酒精中毒、酒精中毒性精神病的药物,饮酒试验时急性二硫龙-乙醇反应的症状是:面红、血压降低、胸闷、心跳加快、呼吸困难、失神、头痛、恶心、呕吐、眼花、愰惚、错乱、痉挛等。二硫龙因阻碍乙醛脱氢酶使血中乙醛浓度上升。日本岐阜大学药理系的虅村一氏小组以上述症状为标准,对十一种头孢菌素的二硫龙样的副作用进行了研究。这十一种头
Recently know that cephalosporin antibiotics have a bit of duloxeitine-like side effects, and has gradually become a topic of discussion. Japan Chemotherapy Society made three special reports on this issue. Disulfirm (diethylcarbamyldisulfate) is a well-known drug for the treatment of chronic alcoholism, alcoholic psychosis. Symptoms of acute dithio-ethanol reaction during drinking tests are: flushing, lowering of blood pressure , Chest tightness, rapid heartbeat, dyspnea, loss of mind, headache, nausea, vomiting, vertigo, trance, confusion, spasms and the like. Dithiocarbodine causes acetaldehyde dehydrogenase to increase blood acetaldehyde concentration. Japan’s Gifu University Department of Pharmacology, Tsuneuraki’s group of the above symptoms as the standard, on the 11 kinds of cephalosporins side effects of dithiocarb were studied. These eleven heads