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近十年来,我们采用化疗配合手术治疗进展期胃癌,特别是改变抗癌药物剂型和用药途径,不但对病人毒性低、副反应小,而且对防治淋巴、腹膜和血行转移,提高进展期胃癌生存期,有一定的作用。现将我们采用的几种方法简要介绍于下,以供同道们参考。一、术前口服5-FU乳剂动物实验发现口服5-FU,12小时测定淋巴结内浓度,乳剂比水剂高10倍。胃癌患者术前经口服5-FU后测定肝内药物浓度,乳剂比水剂高8～14倍。渡边信介报道口服5-FU乳剂后,能向胃壁组织内渗透和滞留,并且有淋巴系统的指向性,所以在胃和附近淋
In the past ten years, we have used chemotherapy in combination with surgery to treat advanced gastric cancer. In particular, we have changed the dosage form and the route of administration of anticancer drugs. We have not only low toxicity and adverse reactions to patients, but also prevent lymphatic, peritoneal, and hematogenous metastasis and improve the survival of advanced gastric cancers. Period, have a certain role. Now we briefly introduce some of the methods we use for reference by our fellow practitioners. First, preoperative oral 5-FU emulsion animal experiments found that oral 5-FU, 12 hours to determine the concentration of lymph nodes, emulsion 10 times higher than the liquid agent. The concentration of intrahepatic drug was measured in patients with gastric cancer after oral administration of 5-FU, and the emulsion was 8-14 times higher than the aqueous solution. Watanabe Shinsuke reported that after oral administration of 5-FU emulsion, it penetrated and retained into the stomach wall tissue, and had the directionality of the lymphatic system, so it was dripping in the stomach and nearby.