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目的:观察吉西他滨联合顺铂治疗晚期食管癌的近期疗效与副反应。方法:80例随机分为治疗组及对照组各40例,治疗组采用吉西他滨联合顺铂方案化疗,共6个周期,对照组采用紫杉醇联合顺铂方案化疗。结果:CR5例、PR16例、SD11例、PD9,总有效率(CR+PR)52%;与对照组相比,治疗组临床症状,生活质量的改善均稍优于对照组,统计学无显著差异(P>0.05)且副反应一致,结论:吉西他滨联合顺铂治疗晚期食管癌有较好的疗效。
Objective: To observe the short-term efficacy and side effects of gemcitabine combined with cisplatin in the treatment of advanced esophageal cancer. Methods: Eighty cases were randomly divided into treatment group and control group, 40 cases each. The treatment group received gemcitabine combined with cisplatin regimen for 6 cycles. The control group received paclitaxel combined with cisplatin regimen. Results: CR5 cases, PR16 cases, SD11 cases, PD9, total effective rate (CR + PR) 52%; compared with the control group, the improvement of clinical symptoms and quality of life in the treatment group were slightly better than the control group, (P> 0.05) and the side reactions were consistent. Conclusion: Gemcitabine combined with cisplatin has a good curative effect on advanced esophageal cancer.