6-硝基吲唑对乏氧细胞有较强的增敏作用,但对正常有氧细胞也有一定的毒性。初步研究降低6-硝基吲唑浓度及合并BSO的离体细胞放射增敏效应。结果表明:BSO可增强6-硝基吲唑的放射增敏效应,单纯用6-硝基吲唑的增敏比为1.73(2mM);用BSO合并6-硝基吲唑的增敏比以Do计为l.83;以Dq计则单纯用6-硝基吲唑及合并BSO的增敏比值分别为1.90和2.95。 6-nitrocarbazole has strong sensitizing effect on hypoxic cells, but it also has certain toxicity to normal aerobic cells. Preliminary studies were conducted to reduce the concentration of 6-nitrocarbazole and radiosensitization of BSO-incorporated ex vivo cells. The results showed that BSO could enhance the radiosensitizing effect of 6-nitrocarbazole, the sensitivity ratio of 6-nitrocarbazole alone was 1.73 (2 mM), and the sensitization ratio of 6-nitrocarbazole was increased by BSO. The Do number was 1.83; the sensitization ratio of pure nitrocarbazole and BSO with Dq was 1.90 and 2.95, respectively.