复发性阿弗他溃疡(recurrent aphthous ucler,RAU)是最常见且治疗较棘手的口腔黏膜病。文章综述国内外文献,根据溃疡复发的临床特征,探讨RAU临床分型,即顽固性RAU和普通性RAU两类。并就目前临床上用于治疗顽固性RAU的药物,如糖皮质激素、沙利度胺、白芍总苷,以及其他免疫调节剂、中医中药等进行综述探讨,以期为临床医生提供帮助。 Recurrent aphthous ucler (RAU) is the most common and more troublesome oral mucosal disease. This article reviews the literature at home and abroad, according to the clinical features of ulcer recurrence, clinical classification of RAU, namely refractory RAU and RAU two categories. At the same time, the clinical trials of drugs for treating refractory RAU, such as glucocorticoids, thalidomide, total glucosides of paeony, as well as other immunomodulatory agents, traditional Chinese medicine and so on, are reviewed to provide help to clinicians.