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目的 探讨庚型肝炎病毒 (HGV)感染对慢性丙型肝炎 (CH -C)的临床与病理学影响。方法 应用逆转录 -聚合酶链反应 (RT -PCR)法对 5 3例经肝穿活检确诊的CH -C患者血清标本进行了HGV -RNA检测 ,并将合并与未合并HGV感染者进行了临床与病理学对比。结果 HGV -RNA阳性 15例 (2 8 30 % )。合并与未合并HGV感染者在临床表现、肝功能等生化指标水平、HCV -RNA阳性率及肝脏病理损害等方面差异均无显著性 (p >0 0 5 )。结论 HGV感染对CH -C的肝脏损害及HCV复制无影响
Objective To investigate the clinical and pathological effects of hepatitis G virus (HGV) infection on chronic hepatitis C (CH-C). Methods HGV-RNA was detected in serum of CH-C patients diagnosed by liver biopsy in 53 cases by reverse transcription-polymerase chain reaction (RT-PCR). The patients with and without HGV infection were studied clinically Contrast with pathology. Results HGV-RNA positive in 15 cases (28%). There was no significant difference in clinical manifestations, biochemical indexes such as liver function, HCV-RNA positive rate and pathological damage of liver between patients with and without HGV infection (p> 0.05). Conclusion HGV infection has no effect on liver damage and HCV replication of CH-C