论文部分内容阅读
目的观察自拟活血通络方泡洗防治紫杉醇所致周围神经毒性的临床疗效。方法将51例接受含紫杉醇方案化疗的恶性肿瘤患者随机分为治疗组26例、对照组25例。对照组无预防性用药,出现外周神经毒性后予甲钴胺片口服,治疗组在对照组治疗方法的基础上,从首次化疗开始每日予自拟活血通络方泡洗,直至化疗结束。在完成紫杉醇药物全部疗程化疗后3周,比较2组患者的周围神经毒性发生率及严重程度。结果治疗组周围神经毒性总发生率为61.5%,对照组为80.0%,2组比较差异无统计意义(P>0.05);治疗组Ⅱ级及以上级别周围神经毒性发生率为26.9%,对照组为56.0%,治疗组显著低于对照组,差异有统计意义(P<0.05)。结论应用紫杉醇化疗时,预防性地给予中药活血通络方泡洗可减轻紫杉醇导致的周围神经毒性,降低周围神经毒性发生的严重程度,改善肿瘤患者的生活质量,值得临床推广。
Objective To observe the curative effect of self-made Huoxuetongluo prescription bubble bath in preventing and treating peripheral neurotoxicity induced by paclitaxel. Methods Totally 51 patients with malignant tumors who received chemotherapy with paclitaxel were randomly divided into treatment group (n = 26) and control group (n = 25). The control group received no prophylactic medication. After the peripheral neurotoxicity was given, the methylcobalamin tablets were given orally. On the basis of the treatment of the control group, the patients in the control group were treated daily for the first time with chemotherapeutic drugs until the end of chemotherapy. Three weeks after completion of the full course of paclitaxel chemotherapy, the incidence and severity of peripheral neurotoxicity in the two groups were compared. Results The total incidence of peripheral neurotoxicity was 61.5% in the treatment group and 80.0% in the control group. There was no significant difference between the two groups (P> 0.05). The incidence of peripheral neurotoxicity in grade Ⅱ and above group was 26.9% 56.0%, the treatment group was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion paclitaxel chemotherapy, the prophylactic administration of traditional Chinese medicine Huoxuetongluo Fang bubble wash can reduce paclitaxel-induced peripheral neurotoxicity, reduce the severity of peripheral neurotoxicity and improve the quality of life of patients with cancer, worthy of clinical promotion.