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目前的研究发现克罗恩病(CD)的发病可能与肠道粘膜防御素(defensin),尤其是β防御素1～3(HBD1～3)功能缺陷密切相关,并且应用外源性抗生素提高肠道粘膜的杀茵能力可以治疗及预防克罗恩病。提示克罗恩病不是一种单一疾病,可能是防御素缺陷的临床综合征。
The current study found that the incidence of Crohn’s disease (CD) may be closely related to the functional defects of intestinal mucosal defensin, especially β-defensin 1 ~ 3 (HBD1 ~ 3), and exogenous antibiotics to improve intestinal Road mucosal killing ability to treat and prevent Crohn’s disease. This suggests that Crohn’s disease is not a single disease and may be a clinical syndrome of defensin deficiency.