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目的探讨保妇康栓联合雌激素软膏治疗老年糖尿病合并阴道炎的临床疗效及其对患者生活质量的影响。方法选取扬州市宝应县人民医院妇科门诊2015—2016年收治的老年糖尿病并阴道炎患者100例。按照抽签法分为联合组与单一组,各50例。单一组患者予以雌激素软膏治疗,联合组患者予以保妇康栓联合雌激素软膏治疗,两组患者均持续治疗2周。比较两组患者临床疗效、治疗前后症状积分、生活质量评价量表(SF-36)评分及血清促卵泡生成素(FSH)和血清雌二醇(E2)水平,观察两组患者不良反应发生情况。结果联合组治疗总有效率为94%,高于单一组的72%(P<0.05)。治疗前两组患者症状积分比较,差异无统计学意义(P>0.05);治疗后联合组症状积分低于单一组(P<0.05)。治疗前两组患者SF-36各项评分及总分、FSH、E2比较,差异无统计学意义(P>0.05);治疗后联合组患者SF-36各项评分及总分、FSH高于单一组,E2低于单一组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论保妇康栓联合雌激素软膏治疗老年糖尿病合并阴道炎的临床疗效确切,可有效缓解患者症状,提升生活质量。
Objective To investigate the clinical efficacy of Baofukang Suppository combined with estrogen ointment in the treatment of senile diabetes mellitus complicated with vaginitis and its effect on the quality of life of patients. Methods A total of 100 elderly patients with diabetes mellitus and vaginitis admitted to gynecology clinic of Baoying People’s Hospital of Yangzhou from 2015 to 2016 were selected. In accordance with the lottery method is divided into a joint group and a single group, 50 cases each. Patients in a single group were treated with estrogen ointment. Patients in the combined group were treated with Baofukang suppository and estrogen ointment. Patients in both groups were treated for 2 weeks. The clinical efficacy, symptom score, SF-36 score, serum levels of FSH and E2 were compared between the two groups. The occurrence of adverse reactions in both groups were observed . Results The total effective rate of the combination group was 94%, higher than that of the single group (72%, P <0.05). There was no significant difference in symptom score between the two groups before treatment (P> 0.05). After treatment, the symptom score in the combined group was lower than that in the single group (P <0.05). There was no significant difference in SF-36 score, total score, FSH and E2 between the two groups before treatment (P> 0.05). SF-36 score and total score in the combined group were higher than single Group, E2 was lower than the single group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Baofukang Suppository combined with estrogen ointment in elderly patients with diabetes mellitus and vaginitis has the exact clinical curative effect, which can effectively relieve the symptoms and improve the quality of life.