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Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role insignal transduction cascade regulating fundamental cellular functions such as transcription,proliferation,andsurvival.PI3Ks also are important in disease processes such as inflammation and cancer.The aim of this review isto outline current understandings of the PI3K family,mechanism of their activation,their role in inflammatoryresponses and the development of malignant tumors.Cellular & Molecular Immunology.2005;2(4):241-252.
Phosphoinositide 3-Kinases (PI3Ks) are proteins coupled to a variety of cell surface receptors and play a key role insignal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, andsurvival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline the current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors. Cellular & Molecular Immunology. 2005; 2 (4): 241-252.