通常认为CTL活化需要CD4+T细胞的辅助。但是在某些动物模型上发现,表达NKG2D配体、CD70/CD80或MHCI类分子缺陷的肿瘤细胞可活化NK细胞进而诱导抗肿瘤CTL应答。CD4+T细胞在NK诱导CTL中的作用尚无定论。研究者首先发现未负载肿瘤抗原的DC可保护小鼠免受致死量B淋巴瘤A20的攻击,抗体清除实验表明这种作用是NK细胞依赖的。体外实验证实,未负载抗原的DC可活化NK细胞,而DC活化 It is generally believed that CTL activation requires the assistance of CD4 + T cells. However, it has been found in some animal models that tumor cells that express defects in NKG2D ligand, CD70 / CD80 or MHC class I molecules can activate NK cells and induce anti-tumor CTL responses. The role of CD4 + T cells in NK-induced CTL is inconclusive. The researchers first found that DCs that were not loaded with tumor antigens protected mice from lethal B lymphoma A20 and antibody clearance experiments showed that this effect was NK cell-dependent. In vitro experiments confirmed that antigen-free DCs can activate NK cells, while DC activation