本文报道茯苓素在小鼠体内、外诱生肿瘤坏死因子的作用。实验表明：茯苓素小鼠体内、外能明显增强经ＢＣＧ预先激活的巨噬细胞产生ＴＮＦ的能力，且有显著的剂量依赖性关系。茯苓素在体内对小鼠移植性肿瘤Ｓ－１８０细胞有明显的抑制生长作用，其作用强弱与ＴＮＦ的水平呈正相关。诱生出的ＴＮＦ可通过抗体中和实验得到确证。 In this paper, Poritis was used to induce tumor necrosis factor in vitro and in vivo in mice. Experiments show that: Poria extract mice in vivo, can significantly enhance pre-activated macrophages BCG TNF-producing capacity, and a significant dose-dependent relationship. Poria cataract has obvious inhibitory effect on S-180 cells transplanted in mice in vivo, and its effect is positively correlated with the level of TNF. Induced TNF can be confirmed by antibody neutralization experiments.