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目的本实验采用立体定向术和新鲜未肝素化血液注入尾状核而建立大鼠脑出血模型，观察用丹皮酚、尼莫通干预后的脑出血组较单纯脑出血组在ｒＣＢＦ、脑水份含量及神经行为学方面的变化。用氢清除法分别测定血肿周围和远隔部位不同时限的ｒＣＢＦ；用干－湿法测定两组大鼠脑出血后４．１２和２４小时Ｒ１，Ｒ２，Ｒ３，Ｂ４部位的脑水份含量；观察两组大鼠在脑出血后不同时限的神经行为学评分的改变。结果 丹皮酚、尼莫通干预的脑出血组血肿周围，远隔部位的ｒＣＢＦ明显增加，脑水份含量降低，神经行为学明显改善与单纯出血组比较有显著差异性（Ｐ≤０．０５或０．０１）
Objective To establish a model of intracerebral hemorrhage in rats by stereotactic and fresh non-heparinized blood injection into the caudate nucleus. The effects of paeonol and nimoton on cerebral hemorrhage were observed in rCBF, Content and neurobehavioral changes. The rCBF was measured by hydrogen scavenging assay at different time points around and within the hematoma. The contents of cerebral water at R1, R2, R3 and B4 at 4.12 and 24 hours after ICH were measured by dry-wet method. The neurobehavioral scores of the two groups were observed at different time points after intracerebral hemorrhage. Results Paeonol and nimotop intervention of cerebral hemorrhage around the hematoma, distant parts of the rCBF increased significantly decreased brain water content, neurological behavior improved significantly compared with the simple bleeding group was significantly different (P ≤ 0.05 or 0.01)