溶瘤腺病毒是继手术、放疗、化疗后治疗肿瘤的新式方法,它能特异性识别并感染肿瘤细胞,最终导致细胞溶胀而摧毁肿瘤细胞,但无法在正常机体细胞内复制而不具有杀伤作用,理论上具有更高的抗肿瘤效应和更低的副作用。目前溶瘤腺病毒Onxy-015(d l 152)已进入Ⅲ期临床试验,文章就溶瘤腺病毒治疗肿瘤的国内外研究进展进行综述。 Oncolytic adenovirus is a new method for the treatment of tumors after surgery, radiotherapy and chemotherapy. It can specifically identify and infect tumor cells, eventually leading to cell swelling and destroying tumor cells, but can not replicate in normal cells without killing effect , In theory, have a higher anti-tumor effect and lower side effects. Currently oncolytic adenovirus Onxy-015 (dl 152) has entered the phase III clinical trials, the article oncolytic adenovirus treatment of cancer research at home and abroad are reviewed.