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肝细胞性肝癌(HCC)的癌前病变是在肝硬化基础上发生的结节性病变,小细胞性改变在各种癌前病变中具有普遍性,分子生物学研究支持其为肝细胞恶性转化的过渡形式。HCC癌前病变主要有异型增生结节与变异肝细胞结节,其中重度异型增生结节与HCC关系最为密切,形态学上结构复杂,与HCC的鉴别有时非常困难,间质血管内皮细胞CD34标记有助于鉴别,必要时需借助分子生物学手段。癌前病变的分子生物学特性及早期癌变机制的研究有利于此类病变的早期诊断及治疗新策略的开发。
Precancerous lesions of hepatocellular carcinoma (HCC) are nodular lesions that occur on the basis of cirrhosis. Minicell changes are prevalent in various precancerous lesions. Molecular biology studies support the malignant transformation of hepatocytes. The transitional form. HCC precancerous lesions are mainly dysplastic nodules and variant hepatocyte nodules. Among them, severe dysplasia nodules are most closely related to HCC. Their morphologically complex structures are sometimes difficult to distinguish from HCC. Interstitial vascular endothelial cells have CD34 markers. It helps to identify, if necessary, the means of molecular biology. The study of the molecular biology characteristics and early cancer mechanism of precancerous lesions is beneficial to the early diagnosis of such lesions and the development of new treatment strategies.