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AIM:To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).METHODS:The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center.The prognostic factors were analyzed with Cox proportional hazard models.RESULTS:GSC tended to occur within 25 years following the primary surgery,when the initial disease is benign,whereas it primarily occurred within the first15 years post-operation for gastric cancer.Patients with regular follow-up after primary surgery had a better survival rate.The multivariate Cox regression analysis revealed that Borrmann type?Ⅰ/Ⅱ(HR=3.165,95%CI:1.055-9.500,P=0.040)and radical resection(HR=1.780,95%CI:1.061-2.987,P=0.029)were independent prognostic factors for GSC.The overall 1-,3-,and 5-year survival rates of the 92 patients were78.3%,45.6%and 27.6%,respectively.The 1-,3-,and 5-year survival rates of those undergoing radical resection were 79.3%,52.2%,and 37.8%,respectively.The 5-year survival rates for stages?Ⅰ,Ⅱ,Ⅲ,andⅣwere 85.7%,47.4%,16.0%,and 13.3%,respectively(P=0.005).CONCLUSION:The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease.Therefore,close follow-up is necessary.The overall survival of patients with GSC is poor,and curative resection can improve their prognosis.
AIM: To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer (GSC) .METHODS: The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center. The prognostic factors were analyzed with Cox proportional hazard models .RESULTS: GSC tended to occur within 25 years following the primary surgery, when the initial disease is benign, and it occasionally within the first 15 years post-operation for gastric cancer. Patients with regular follow-up after primary surgery had a better survival rate. multivariate Cox regression analysis revealed that Borrmann type Ⅰ / Ⅱ (HR = 3.165,95% CI: 1.055-9.500, P = 0.040) and radical resection (HR = 1.780,95% CI: 1.061-2.987, P = 0.029) were independent prognostic factors for GSC. Overall 1-, 3-, and 5-year survival rates of the 92 patients were 78.3%, 45.6% and 27.6% respectively.The 1-, 3-, and 5-year survival rates of those undergoing radical resections were 79.3%, 52.2%, and 37.8% respectively The 5-year survival rates for stages Ⅰ, Ⅱ, Ⅲ, and Ⅳwere 85.7%, 47.4%, 16.0%, and 13.3%, respectively (P = 0.005) .CONCLUSION: The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease.Therefore, close follow-up is necessary. overall survival of patients with GSC is poor, and curative resection can improve their prognosis.