论文部分内容阅读
目的研究膳食铁摄入量、机体内铁负荷与代谢综合征的关系。方法选择代谢综合征患者87例,健康对照102例,7天膳食回顾法调查膳食铁摄入情况,检测血清铁、血清铁蛋白、运铁蛋白饱和度等铁营养状况,以及血糖、血脂、丙二醛(MDA)、超氧化物歧化酶(SOD)、NF-κB等。结果代谢综合征患者膳食铁摄入量、动物来源铁摄入量、MDA、NF-κB水平显著高于健康对照,而血清铁蛋白、血清铁、运铁蛋白饱和度、血清SOD水平低于健康对照。相关关系分析发现,血清铁与胰岛素抵抗指数、血糖呈正相关;以总膳食铁摄入大于15mg/d作为铁摄入过量,总铁摄入过量者罹患MS的OR=7.12,而以动物来源铁大于7.5mg/d作为铁摄入过量的标准,则铁摄入过多对MS的OR=7.73;多因素logistic回归分析结果表明,脂肪和动物来源铁摄入量是MS的影响因素。结论动物来源膳食高铁摄入可导致体内铁过负荷,铁过负荷可能与代谢综合征发病有关。
Objective To study the relationship between dietary iron intake, body iron load and metabolic syndrome. Methods Eighty-seven patients with metabolic syndrome, 102 healthy controls and 7-day dietary recalls were enrolled in the study to investigate dietary iron intake, serum iron, serum ferritin, transferrin saturation and other iron nutrition status, blood glucose, blood lipid, Dialdehyde (MDA), superoxide dismutase (SOD), NF-κB and so on. Results Dietary iron intake, iron intake in animals, MDA and NF-κB in patients with metabolic syndrome were significantly higher than those in healthy controls, while serum ferritin, serum iron, transferrin saturation and serum SOD levels were lower than those in healthy controls Control. Correlation analysis found that serum iron and insulin resistance index, blood glucose was positively correlated; with total dietary iron intake of more than 15mg / d as iron overdose, total iron intake overdose were associated with MS OR = 7.12, while animal-derived iron When the iron intake was higher than 7.5mg / d as the standard of iron overdose, OR of excessive iron intake to MS was 7.73. Multivariate logistic regression analysis showed that iron intake of fat and animals was the influencing factor of MS. Conclusion Ingestion of high-iron dietary intake from animal sources may lead to over-iron overload in the body, which may be related to the pathogenesis of metabolic syndrome.