目的 :探讨干扰素的神经系统副作用及其发生机理。方法 :对 12 0例患者采用干扰素治疗时出现的精神神经症状进行临床统计分析。结果 :本组干扰素诱导的精神症状的发生率为 77.5 % (93/ 12 0 ) ,失眠、烦躁、焦虑及抑郁的发生率分别为 77.5 %、45 .8%、30 .8%及 19.2 %。结论 :干扰素诱导的精神神经症状发生率高 ,女性多于男性 ,与用药剂量有关 ,后果严重 Objective: To explore the nervous system side effects of interferon and its mechanism. Methods: A clinical statistical analysis was performed on neuropsychiatric symptoms in 120 patients treated with interferon. Results: The incidence of psychotic symptoms induced by interferon in this group was 77.5% (93/12 0), the incidences of insomnia, irritability, anxiety and depression were 77.5%, 45.8%, 30.8% and 19.2%, respectively . Conclusion: Interferon-induced neuropsychiatric symptoms have a high incidence, more women than men, with the dose, the serious consequences