本文报告是文献上第一例晚期何杰金氏病发生慢粒原始细胞危象,治疗后取得长期缓解者。患者男性18岁,1871年诊断HDIA,混合细胞型,经颈淋巴结放疗后取得完全缓解。一年后,腹部淋巴结肿大,再予放疗。二年后第二次复发,且伴全身症状,用MOPP方案6疗程,又取得完全缓解。1976年见白细胞增多,Ph~1染色体(+),确诊慢粒,间歇马利兰治疗9年,1985年6月乏力、发热、大量出汗、食欲减退,白细胞数达77×10~9/L,原始细胞60%,骨髓检查原始粒细胞61%,染色体检查见双倍体Ph~1及三倍体,且伴发金葡球菌败血症。化疗应用M-Ams_2~a This paper reports the first case of late onset Hodgkin’s disease in the literature of CML crisis and long-term remission after treatment. The patient, male, was 18 years old and diagnosed HDIA in 1871 with mixed cell type and achieved complete remission after radiotherapy of cervical lymph nodes. A year later, abdominal lymph nodes, and then radiotherapy. Second relapse two years later, and with systemic symptoms, with MOPP program 6 courses, and achieved complete remission. In 1976, there were leukocytosis, Ph chromosome (+), diagnosed as CML, intermittent marilan for 9 years, fatigue in June 1985, fever, massive sweating and loss of appetite. The number of white blood cells reached 77 × 10 ~ 9 / L, 60% of primary cells, 61% of myeloblasts in bone marrow, chromosomes Ph ~ 1 and triploids in chromosomes, and Staphylococcus aureus septicemia. Chemotherapy application M-Ams_2 ~ a