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To identify the role of circulating immune factor(s) in the development of proteinuria, the supernatant of peripheral blood mononuclear cells (PBMC) were obtained from 15 patients with steriod-responsive nephrotie syndrome, and its effect on the synthesis of sulfated compound by cultured rat glomerular epithelial cell (GEC) were studied by ~(35)S, ~3H-leucine dual-isotope labelling technique. The result showed that the supernatant of PBMC from 9 patients without steroid treat ment increased ~(35)S uptake in GEC (P<0.01), while there was no significant difference in ~(35)S uptake between the 6 patients treated with prednisone (1.5-2.0 mg/kg.d~(-1)) and 6 normal controls.
To identify the role of circulating immune factor (s) in the development of proteinuria, the supernatant of peripheral blood mononuclear cells (PBMC) were obtained from 15 patients with steriod-responsive nephrotie syndrome, and its effect on the synthesis of sulfated compound by cultured The result showed that the supernatant of PBMC from 9 patients without steroid treat ment increased ~ (35) S uptake in GEC (GEC) were studied by ~ (35) S, ~ 3H-leucine dual-isotope labeling technique (P <0.01), while there was no significant difference in ~ (35) S uptake between the 6 patients treated with prednisone (1.5-2.0 mg / kg.d -1) and 6 normal controls.