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本文作者评价了HBsAg阴性母亲所生婴儿对乙型肝炎疫苗的免疫应答情况,同时对加速免疫程序和传统的间隔时间较长的免疫程序的效果进行了比较。 作者共选择了408名HBsAg阴性母亲所生的健康足月婴儿和早产儿,其中男性208人,女性200人;371名为足月儿,37名为早产儿;135人为母乳喂养,273人应用奶制品。将婴儿随机分为两组,A组（183人）以加速免疫程序（0、1、3月）进行免疫;B组（225人）以传统免疫程序（0、1、6月）进行免疫。用重组乙型肝炎疫苗（EngerixB）作肌肉注射,每剂10μg。对所有婴儿均采集两份血液样本（每份1.5ml）,第1份于第1针免疫前采集。第2份,A组于第4月、B组于第7月采集。用ELISA测定抗-HBs浓度。抗-HBs水平≥100mIU/ml视为高应答者,低于10mIU/ml为低应答者,不能测出抗体者为无应答者。 结果表明,在免疫前,两组婴儿的抗-HBs均为阴性。在完成免疫后1个月,A组有100人（54.6％）、B组有196人（87.1％）抗-HBs浓度≥100mIU/M。两组中抗-HBs浓
The authors evaluated the immune response to hepatitis B vaccine in infants born to mothers with HBsAg-negative mothers and compared the effects of the accelerated immunization schedule and the traditional longer-duration immunization schedule. The authors selected a total of 408 healthy term infants and preterm infants born to HBsAg negative mothers, including 208 males and 200 females; 371 were term infants and 37 were premature infants; 135 were breastfeeding and 273 were used Dairy products. Infants were randomized into two groups, Group A (183) immunized with an accelerated immunization schedule (0, 1, 3 months); Group B (225) immunized with a conventional immunization schedule (0, 1, 6 months). Recombinant hepatitis B vaccine (EngerixB) for intramuscular injection, each dose of 10μg. Two blood samples (1.5ml each) were collected for all infants and the first was collected before the first immunization. The second, group A in April and group B in July. Anti-HBs concentrations were determined by ELISA. Anti-HBs levels ≥ 100mIU / ml as high responders, less than 10mIU / ml as a low responder, can not be detected as non-responders. The results showed that both groups of infants had negative anti-HBs before immunization. One month after completion of immunization, 100 (54.6%) in group A and 196 (87.1%) in group B had an anti-HBs concentration of 100 mIU / M. Anti-HBs concentration in both groups