论文部分内容阅读
经慢性埋藏导管给清醒家兔侧脑室分别注射去甲肾腺素及其拮抗剂——妥拉苏林、心得安后,记录皮层脑电图的改变。结果:注入去甲肾上腺素后,β波明显增多,δ、θ波不仅频率减少,波幅也显著降低,表现出皮层去同步化的激醒作用。相反注入妥拉苏林则出现δ、θ波明显增多,波幅增高的同步化现象;而注入心得安后对脑电波无明显的规律性的变化。当静脉注射氯丙嗪脑电波出现大慢波后,再由侧脑室注入去甲肾上腺素,则不再出现皮层的去同步化作用。提示去甲肾上腺素经中枢内的α受体对皮层有激醒作用,去甲肾上腺素可能是作用于脑干而引起皮层脑电变化的。
After chronic burial catheter was injected into the lateral ventricle of awake rabbits respectively, norepinephrine and its antagonist - tolazulin, propranolol, record cortical EEG changes. Results: After injection of norepinephrine, β wave increased significantly, δ, θ wave not only decreased in frequency, the amplitude was also significantly reduced, showing cortical desynchronization of the awakening effect. On the contrary, the injection of torathulin appeared δ, θ wave significantly increased, the amplitude of the synchronization phenomenon; and injection of the security after the brain waves no obvious regular changes. When intravenous injection of chlorpromazine brain waves appear after a large slow wave, and then into the lateral ventricle of norepinephrine, the cortex no longer appear to be synchronized. It is suggested that norepinephrine may have an arousal effect on the cortex through the central α receptor. Norepinephrine may act on the brain stem and cause cortical EEG changes.