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目的 :检测胃癌患者血清癌胚抗原 (CEA)、糖链抗原 (CA50 )和转化生长因子 -α(TGF-α)的水平变化及临床意义。方法 :采用放射免疫法和微粒子化学发光免疫法对 78例胃癌 ,1 0例重度胃粘膜不典型增生患者及 30例健康人血清的 CEA、CA50和 TGF- α作了检测。结果 :各期胃癌血清 CEA、CA50和 TGF-α值均明显高于正常对照组 (P<0 .0 5) ; 、 期胃癌的 CEA、CA50水平又显著高于 、 期胃癌组 (P<0 .0 1 ) ; 、 期胃癌的 TGF-α水平与 、 期组差异无显著性 (P>.0 .0 5) ,重度胃粘膜不典型增生组的 CEA、CA50与正常对照组差异无显著性 ,但 TGF- α值明显高于对照组 (P<0 .0 5) ,几乎接近胃癌水平。结论 :检测 TGF- α和 CEA、CA50 ,进行多参数分析 ,可作为判断病程进展及预后的辅助指标 ,其中 TGF-α可作为胃癌癌前病变的一项有意义指标之一。
Objective: To detect the changes of serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA50) and transforming growth factor-α (TGF-α) in patients with gastric cancer and its clinical significance. Methods: Serum levels of CEA, CA50 and TGF-α in 78 cases of gastric cancer, 10 cases of atypical hyperplasia of gastric mucosa and 30 cases of healthy people were detected by radioimmunoassay and microparticle chemiluminescence immunoassay. Results: The serum levels of CEA, CA50 and TGF-α in each stage of gastric cancer were significantly higher than those in normal control group (P <0.05), and the levels of CEA and CA50 in gastric cancer were significantly higher than those in stage of gastric cancer (P <0. 05) 0.05). There was no significant difference in the levels of TGF-α in gastric cancer between the two groups (P> 0.05), but there was no significant difference between CEA and CA50 in severe gastric mucosa dysplasia group and normal control group , But TGF-α was significantly higher than the control group (P <0.05), almost close to the level of gastric cancer. Conclusion: The detection of TGF-α, CEA, CA50, multi-parameter analysis can be used as an adjunct to judge the progression of disease and prognosis. Among them, TGF-α can be used as one of the significant indexes of gastric precancerous lesions.