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目的:建立简易、稳定性高的家兔肾下腹主动脉瘤模型。方法:选取健康雄性家兔32只设立盐水灌注对照,采用弹力蛋白酶灌注肾下腹主动脉的方法进行模型制作,利用不同染色方法,分别于术后2天,7天取标本观察灌注段腹主动脉的成瘤情况,形态学变化及病理改变。结果:8只弹力蛋白酶灌注术后7天组有6只存活,腹主动脉直径扩张均大于100%,与各对照组相比差异有统计学意义。病理改变体现为炎性细胞浸润,血管中层弹力组织破坏。结论:家兔腹主动脉瘤模型操作简易,病理特征稳定,建模成功率较高。
Objective: To establish a simple and stable model of rabbit renal lower abdominal aortic aneurysm. Methods: Thirty-two healthy male rabbits were randomly divided into three groups: control group, saline group, control group, and control group. Thirty-two healthy male rabbits were selected to establish saline control group. Erythrocyte abdominal aorta was perfused with elastase, and different staining methods were used to observe the abdominal aorta The tumor formation, morphological changes and pathological changes. Results: There were 6 surviving 7 days after the 8 elastase infusion and the diameter of the abdominal aorta were all larger than 100%. There were significant differences compared with the control group. Pathological changes manifested as inflammatory cell infiltration, vascular tissue damage to the middle layer. Conclusion: The model of abdominal aortic aneurysm in rabbits has simple operation, stable pathological features and high success rate of modeling.