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目的:考察小剂量5-氟尿嘧啶(5-Fu)联合卡介菌多糖核酸(BCG-PSN)治疗尖锐湿疣(CA)的临床疗效。方法:将80例CA患者随机分为治疗组42例,于CA基底部缓缓注入5-Fu混合注射液(每10ml 5-Fu加入普鲁卡因肾上腺素注射液2ml),注射量以疣体恰与正常组织分离为度(总量最多不超过10ml即5-Fu≤200mg),隔日1次,直至疣体萎缩或脱落。同时肌注BCG-PSN注射液,每次1ml,每周2次,连用3个月;对照组38例,只给予5-Fu病损基底部注射治疗,方法同治疗组;另设30例无CA的健康志愿者为正常组,以备检测健康人群血清白细胞介素2(IL-2)含量。结果:治疗前治疗组和对照组CA患者血清IL-2含量均显著低于正常组健康人群(P<0.05),治疗后治疗组的血清IL-2含量有明显提高(P<0.05),对照组的血清IL-2含量变化却无统计学差异(P>0.05);治疗组的治愈率显著高于对照组(P<0.01),复发率远低于对照组(P<0.01)。结论:小剂量5-Fu联合BCG-PSN治疗CA治愈率高,复发率低。
Objective: To investigate the clinical efficacy of low-dose 5-fluorouracil combined with BCG-PSN in the treatment of condyloma acuminatum (CA). Methods: Eighty patients with CA were randomly divided into treatment group (n = 42), 5-Fu mixed injection (2ml procaine adrenaline injection per 10ml 5-Fu) Body just and normal tissue separation degree (the total amount of not more than 10ml or 5-Fu ≤ 200mg), every other day until the wart atrophy or fall off. At the same time intramuscular injection of BCG-PSN injection, each 1ml, 2 times a week, once every 3 months; control group 38 cases, only given 5-Fu lesions at the base of the injection treatment, the same treatment group; The healthy volunteers of CA were normal group, in order to detect the content of serum interleukin 2 (IL-2) in healthy population. Results: Before treatment, the level of IL-2 in serum of CA patients in treatment group and control group was significantly lower than that in normal group (P <0.05), and the level of IL-2 in treatment group was significantly increased (P <0.05) (P> 0.05). The cure rate of the treatment group was significantly higher than that of the control group (P <0.01), and the recurrence rate was much lower than that of the control group (P <0.01). Conclusion: Small-dose 5-Fu combined with BCG-PSN has a high cure rate and low recurrence rate.