采用ＦＰＬＣ快速纯化人血清白蛋白，利用双功能试剂２－亚胺基－２－甲氧基乙基－１－疏代－ 半乳糖甙与伯胺基的成脒反应，将硫代半乳糖残基引入人血清白蛋白分子，得到平均糖密度为 ３０的新半乳糖人血清白蛋白（ＮＧＡ）；用直接法制备９９ｍＴｃ－ＮＧＡ，其放化纯大于９０％，且室温下 可稳定６ｈ以上，符合显像要求。９９ｍＴｃ－ＮＧＡ小鼠体内分布实验及大鼠、兔和狗的显像研究均 表明９９ｍＴｃ－ＮＧＡ能够被肝脏特异摄取，且具有饱和性，主要通过胆道、肠道排泄，是一种较 好的肝ＡＳＧＰ受体功能显像剂。 Rapid purification of human serum albumin by FPLC, the use of bifunctional reagent 2-Imino-2-methoxyethyl-1-sparse-galactoside and primary amino amidine reaction, the thio galactose residue The introduction of human serum albumin molecules, the average sugar density of 30 to obtain a new galactose human serum albumin (NGA); prepared by direct 99mTc-NGA, its pure radiochemical greater than 90%, and stable at room temperature more than 6h, Meet the imaging requirements. 99mTc-NGA mice in vivo distribution studies and rat, rabbit and dog imaging studies have shown that 99mTc-NGA can be specifically absorbed by the liver, and has saturation, mainly through the biliary and intestinal excretion, is a good liver ASGP receptor functional imaging agent.