目的 :对比观察国产辛代他汀与进口辛伐他汀 (舒降之 )对高脂血症患者的调血脂作用。　　方法 :将 16 0例高脂血症患者以抽签法随机分为辛伐他汀组 (n=10 0 )及舒降之组 (n=6 0 ) ,分别口服国产辛伐他汀及舒降之。观察用药 4周及 8周患者的血清总胆固醇 (TC) ,低密度脂蛋白胆固醇 (L DL- C) ,高密度脂蛋白胆固醇 (HDL- C) ,(TC- HDL- C) /HDL- C及甘油三酯 (TG)变化。　　结果 :服用国产辛伐他汀 4周及 8周可分别使患者血清 TC降低 2 2 .8%、2 8.1% ,L DL - C降低 2 7.9%、32 .2 % ,(TC-HDL- C) /HDL- C降低 36 .3%、45 .2 % ,HDL- C升高 13.4%、16 .1% ,合并高甘油三酯血症患者 TG降低 19.4%、2 9.4% ,但对单纯高胆固醇血症患者 TG水平无显著影响。服药 4周即有明显调血脂疗效。　　结论 :国产辛伐他汀调血脂作用疗效肯定 ,与其相应进口产品舒降之比较基本相同。 OBJECTIVE: To compare the blood lipid regulation effect of domestic and imported simvastatin (SHR) in patients with hyperlipidemia. Methods: One hundred and sixty patients with hyperlipidemia were randomly divided into simvastatin group (n = 100) and Shuzheng group (n = 60) by random selection. The levels of total cholesterol (TC), low density lipoprotein cholesterol (L DL-C), high density lipoprotein cholesterol (HDL-C), (TC- HDL- C) / HDL- C And triglyceride (TG) changes. Results: After 4 weeks and 8 weeks of treatment with domestic simvastatin, the levels of serum TC decreased by 2.2 8%, 21 8.1%, and decreased by 25.9%, 32.2%, respectively (TC-HDL-C) / HDL-C decreased by 36.3%, 45.2%, HDL-C increased by 13.4%, 16.1%, TG decreased 19.4%, 2 9.4% in patients with hypertriglyceridemia, but the simple hypercholesteremia Serum TG levels had no significant effect. Medication 4 weeks that there is significant blood lipid-lowering effect. Conclusion: The effect of home-made simvastatin on lipid-lowering effect is definite, which is basically the same as that of its corresponding imported product.