论文部分内容阅读
自从阿司匹林损伤人胃粘膜得到证实以来,非甾体抗炎药(NSAID)与消化道溃疡的关系被广泛研究。文献报道阿司匹林致胃溃疡的相对危险校正值为4.67,NSAID 为4.03。上消化道出血与阿司匹林相关联,平均相对危险值为3.30,NSAID 与上消化道出血平均相对危险值为3.09,穿孔为5.93。文献报道,死于溃疡或其并发症者也具一致关系,NSAID 平均相对危险值为7.62。扑热息痛也与胃溃疡和上消化道出血有关。然而,几组对照病例研究未能证实 NSAID 可导致单纯十二指肠溃疡。NSAID 可影响血小板功能,使出血时间延长,表现为:①非溃疡性病变所致上胃肠道出血增多;②连续服用阿司匹林近3个月者,半数病例发生出血;③出血的最大危险发生于
The relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and gastrointestinal ulcers has been extensively studied since aspirin has been shown to damage human gastric mucosa. Reported in the literature of aspirin cause gastric ulcer relative risk correction was 4.67, NSAID was 4.03. Upper gastrointestinal bleeding was associated with aspirin, with an average relative risk of 3.30, an average relative risk of NSAID and upper gastrointestinal bleeding of 3.09, and a perforation of 5.93. Reported in the literature, died of ulcers or its complications are also consistent, the average relative risk of NSAID was 7.62. Paracetamol is also associated with gastric ulcer and upper gastrointestinal bleeding. However, several groups of controlled case studies failed to demonstrate that NSAIDs can lead to simple duodenal ulcers. NSAID can affect platelet function, prolonged bleeding time, manifested as: ① non-ulcer lesions caused by gastrointestinal bleeding increased; ② continuous administration of aspirin nearly 3 months, half of the cases of bleeding; ③ the greatest risk of bleeding occurred in