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偏头痛患者血小板α颗粒膜蛋白140(GMP—140)水平的变化,国内尚未见报道。我们测定了22例偏头痛急性发作期和缓解期患者的血浆GMP—140水平,并对血小板在偏头痛发生中的作用进行了探讨,现报告如下。 资料与方法:22例患者中,男7例,女15例;平均年龄36.5±7.8岁;病程1～18年,平均8.4±6.3年。典型偏头痛2例,普通偏头痛20例,均按国际头痛分类及诊断标准确诊,且排除肝、肾、心脑血管病及内分泌代谢疾病。另设正常对照组28例,无头痛及其他疾病病史(男11例,女17例;平均年龄33.2±6.1岁)。 偏头痛患者分别于头痛发作1周内和3周后两
Migraine patients with platelet α-granule membrane protein 140 (GMP-140) level changes, has not been reported in China. We measured the plasma levels of GMP-140 in 22 migraine attacks and remission episodes and explored the role of platelets in migraine. We report the following. Materials and Methods: Among the 22 patients, there were 7 males and 15 females with an average age of 36.5 ± 7.8 years. The course of disease ranged from 1 to 18 years with an average of 8.4 ± 6.3 years. Two cases of typical migraine and 20 cases of common migraine were diagnosed according to the international classification of headache and diagnostic criteria, and excluding liver, kidney, cardiovascular and cerebrovascular diseases and endocrine and metabolic diseases. Another 28 cases of normal control group, no history of headache and other diseases (11 males and 17 females; mean age 33.2 ± 6.1 years). Migraine patients were headache attack within 1 week and 3 weeks after two