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目的:探讨尿激酶对恶性胸腔积液伴纤维多分隔的治疗效果。方法:将40例恶性胸腔积液伴纤维多分隔患者分成两组,每组20例,分别予以胸腔应用尿激酶后再注入铂类药物(尿激酶组)和胸腔加压注入生理盐水后再注入铂类药物(生理盐水组)治疗,比较两种方法的治疗效果。结果:恶性胸腔积液尿激酶组完全缓解(CR)13例,部分缓解(PR)4例,无效(NC)3例;生理盐水组CR 3例,PR 4例,NC 13例。结论:对恶性胸腔积液伴纤维多分隔患者胸腔注入尿激酶后再注入铂类药物化疗可以提高缓解率。
Objective: To investigate the therapeutic effect of urokinase on malignant pleural effusion with multiple fibroids. Methods: Forty patients with malignant pleural effusion and multiple fibroids were divided into two groups (n = 20 each). Thirty patients were treated with thrombolytic therapy of urokinase before injection of platinum drug (urokinase group) and saline injection of pleural pressure Platinum drugs (saline group) treatment, the treatment effect of the two methods are compared. Results: Thirteen cases of complete remission (CR), partial remission (PR) in 4 cases, and ineffective (NC) in 3 cases of malignant pleural effusion urokinase group, 3 cases of CR in CR group and 13 cases of NC in saline group. CONCLUSIONS: The response rate of patients with malignant pleural effusion and fibroepithelial pleural injection of urokinase before injection of platinum drug chemotherapy can improve the remission rate.