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目的探讨食管鳞状细胞癌中DNA结合抑制蛋白-1(inhibitors of DNA binding 1,ID-1) 与Ki-67及Bcl-2表达的关系及其临床意义。方法应用免疫组织化学方法检测118例食管鳞状细胞癌手术切除标本及20例癌旁正常组织中ID-1、Ki-67及Bcl-2的表达情况。结果食管鳞状细胞癌中ID-1、Ki-67及Bcl-2表达上调,阳性比例分别为86.44%、81.36%和59.32%;ID-1及Bcl-2表达程度与肿瘤组织分化程度正相关(分别为r=0.289,P=0.002;及r=0.319,P=0.001);Ki-67表达程度与肿瘤组织分化程度负相关(r=-0.320,P<0.001);ID-1与Bcl-2表达正相关而与Ki-67表达无关; ID-1、Ki-67及Bcl-2表达与患者的年龄、性别及是否伴淋巴结转移均无关。结论细胞凋亡抑制可能是ID-1参与食管鳞状细胞癌发生发展的主要机制,ID-1不适用于评价食管鳞状细胞癌的淋巴结转移。
Objective To investigate the relationship between the expression of inhibitors of DNA binding 1 (ID-1) and Ki-67 and Bcl-2 in esophageal squamous cell carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of ID-1, Ki-67 and Bcl-2 in 118 cases of esophageal squamous cell carcinoma and 20 cases of adjacent normal tissues. Results The expressions of ID-1, Ki-67 and Bcl-2 were up-regulated in esophageal squamous cell carcinoma with positive rates of 86.44%, 81.36% and 59.32%, respectively. The positive rates of ID-1 and Bcl- (R = 0.289, P = 0.002; r = 0.319, P = 0.001). The expression of Ki-67 was negatively correlated with the degree of tumor differentiation 2 expression but not Ki-67 expression. The expression of ID-1, Ki-67 and Bcl-2 had no correlation with age, gender and lymph node metastasis. Conclusions The inhibition of apoptosis may be the main mechanism of ID-1 in the development of esophageal squamous cell carcinoma. ID-1 is not suitable for evaluating the lymph node metastasis of esophageal squamous cell carcinoma.