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目的：观察比较度洛西汀、西肽普兰对伴有躯体疼痛症状的抑郁症患者血浆P物质水平的影响。方法伴有躯体疼痛症状的抑郁症患者随机分组，分别接受度洛西汀（60 mg/d，n＝25），西肽普兰（20～40 mg/d，n＝25）治疗，于治疗前、治疗4、8周末分别测定血浆P物质水平。结果①度洛西汀组治疗4、8周末的血浆P物质水平均较治疗前显著下降（ t＝2．095，3．504；P＝0．046，0．003）；西肽普兰组治疗8周末，血浆P物质水平较治疗前显著下降（ t＝2．170， P＝0．040）；②治疗前、治疗4周末，度洛西汀组、西肽普兰组血浆P物质水平无显著差异；治疗8周末，度洛西汀组血浆P物质水平显著低于西肽普兰组（t＝2．030，P＝0．047）。结论度洛西汀、西肽普兰均可使伴躯体疼痛症状的抑郁症患者血浆SP水平下降，但度洛西汀起效更快、作用更强。“,”Objective To investigate the effect of duloxetine and citalopram on substance P in major depression patients with somatic pain.Methods Depressed inpatients with pain symptom of body were randomly divided into two groups treated with duloxetine (60mg/d,n=25) or citalopram(20~40mg/d,n=25) and measured by serum SP obtained from external jugular vein .Results The plasma levels of substance P were significantly reduced after 4,8 weeks duloxetine treatment (t=2.095,3.504;P=0.046,0.003) or 8 weeks citalopram treatment (t=2.170,P=0.040).The plasma levels of substance P showed no significant difference between two groups be -fore and after 4 weeks treatment ,but the plasma levels of substance P were significantly lower in depressed patients treated with duloxe -tine compared to those treated with citalopram (t=2.030,P=0.047).Conclusion Duloxetine or Citalopram should have effects on down-regulating the plasma levels of substance P in major depression patients with somatic pain ,which is rapider and stronger in the former than that in the later .