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天然免疫存在于所有的多细胞生物中,是机体抵抗病原微生物的第一道防线。机体对病原微生物的天然免疫反应涉及到多基因多层次的转录、翻译和翻译后调控的复杂过程。果蝇在受到病原微生物感染时,会通过激活天然免疫信号途径分泌许多抗菌肽分子,这些分子分泌到血淋巴细胞后能杀死入侵的病原微生物。Toll信号通路是目前了解最多的果蝇抗菌肽产生的一条信号通路,但其具体分子调节机制仍不完全清楚。
Natural immunity exists in all multicellular organisms, the body’s first line of defense against pathogenic microorganisms. The body’s natural immune response to pathogenic microorganisms involves a complex process of multi-gene, multilevel transcription, translation and post-translational regulation. When infected by pathogenic microorganisms, Drosophila secrete many antimicrobial peptide molecules through the activation of innate immune signaling. These molecules can kill invading pathogenic microorganisms after being secreted into blood lymphocytes. Toll signaling pathway is one of the most widely understood signal transduction pathways produced by Drosophila antimicrobial peptides, but its molecular regulation mechanism is still not fully understood.