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目的 :研究抑癌基因PTEN和半胱氨酸蛋白酶Caspase 3在喉鳞状细胞癌中的表达及临床意义。 方法 :应用免疫组织化学SP法检测 2 0例正常喉组织、6 0例声带不典型增生、2 89例喉癌组织中PTEN ,Caspase 3的表达。结果 :正常喉组织、声带不典型增生、喉癌组织中PTEN阳性表达率分别为 10 0 .0 %、86 .7%、5 8.8% ,三者之间差异具有统计学意义 (均 P <0 .0 5 ) ;Caspase 3阳性表达率分别为 85 .0 %、6 1.7%、4 8.1% ,三者之间差异具有统计学意义 (均P <0 .0 5 )。另外 ,Caspase 3与PTEN在喉癌中的表达具有正相关性 (P <0 .0 1)。结论 :喉鳞状细胞癌中抑癌基因PTEN ,Caspase 3的表达异常可能与喉癌的发生、发展有关。
Objective: To study the expression and clinical significance of tumor suppressor gene PTEN and caspase 3 in laryngeal squamous cell carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of PTEN and Caspase 3 in 20 normal laryngeal tissues, 60 cases of vocal cord dysplasia and 2 89 cases of laryngeal cancer. Results: The positive rates of PTEN in normal laryngeal tissues, atypical hyperplasia of vocal cord and in laryngeal carcinoma were 100.0%, 86.7% and 58.8%, respectively (all P <0 .05). The positive rates of Caspase 3 were 85.0%, 67.1% and 4.81%, respectively (all P <0.05). In addition, there was a positive correlation between the expression of Caspase 3 and PTEN in laryngeal carcinoma (P <0.01). Conclusion: The abnormal expression of tumor suppressor genes PTEN and Caspase 3 in laryngeal squamous cell carcinoma may be related to the occurrence and development of laryngeal carcinoma.