囊性纤维化（Ｃｙｓｔｉｃｆｉｂｒｏｓｉｓ，ＣＦ）是白种人最常见的致死性常染色体隐性遗传病，发病率以北欧人群最高，约占活婴的１／２５００，致病基因携带率为１／２５。但近年来的研究发现，ＣＦ基因突变率在梗阻性无精子症患者中高达５０％～８２％。随着近几年辅助生 Cystic fibrosis (CF) is the most common fatal autosomal recessive disease in Caucasians. The incidence is highest in the Nordic population, accounting for 1/2500 of that of live infants. The incidence of pathogenic gene carrier is 1/25 . However, recent studies have found that CF gene mutation rate in obstructive azoospermia in up to 50% to 82%. With the help of students in recent years