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目的探讨呼出气一氧化氮呼气测定(fractional exhaled nitric oxide Fe NO)在支气管哮喘中的诊疗作用。方法选取在我院收治的支气管哮喘患者143例,给予为期4周的布地奈德福莫特罗(信必可都保160/4.5?g,bid)吸入治疗,检测治疗前后Fe NO、肺功能、支气管激发试验。结果吸入布地奈德福莫特罗治疗后较治疗前Fe NO值显著降低(P<0.05),同时FEV1%pred治疗后较治疗前明显改善(P<0.05),Dmin治疗后较治疗前明显降低(P<0.05)。在治疗前患者Fe NO水平与FEV1/pred%无直线相关性,与Dmin呈负相关(r=-0.534,P<0.001)。治疗后Fe NO水平与FEV1/pred%亦无直线相关,但与Dmin仍呈负相关,治疗前FEV1/pred%与Dmin显著相关(r=0.438,P<0.01)。结论在支气管哮喘的诊疗中,Fe NO可以作为气道炎症程度的重要参考指标,与肺功能及支气管激发试验可以更好地反应哮喘疾病控制程度。
Objective To investigate the diagnostic and therapeutic effects of fractional exhaled nitric oxide (NO) in bronchial asthma. Methods 143 patients with bronchial asthma admitted in our hospital were given inhalation of budesonide formoterol (Docetaxel 160 / 4.5? G, bid) for 4 weeks. The levels of Fe NO, pulmonary function before and after treatment , Bronchial provocation test. Results After inhaled budesonide formoterol treatment, the Fe NO value was significantly lower than that before treatment (P <0.05), and the FEV1% pred treatment was significantly improved after treatment (P <0.05). After Dmin treatment, it was significantly lower than that before treatment (P <0.05). There was no linear correlation between Fe NO level and FEV1 / pred% before treatment, but negatively correlated with Dmin (r = -0.534, P <0.001). There was no linear correlation between FeNO level and FEV1 / pred% after treatment, but it was negatively correlated with Dmin. FEV1 / pred% was significantly correlated with Dmin before treatment (r = 0.438, P <0.01). Conclusion In the diagnosis and treatment of bronchial asthma, Fe NO can be used as an important reference index for the degree of airway inflammation, and lung function and bronchial provocation test can better reflect the degree of asthma control.