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目的:观察门冬氨酸鸟氨酸在预防肝硬化合并上消化道出血所诱发肝性脑病的临床疗效观察。方法:抽取了我院2009年~2014年我院收治的肝硬化合并上消化道出血病例250例,其中上消化道出血后早期预防性应用门冬氨酸鸟氨酸的病例128例,早期未给予门冬氨酸鸟氨酸治疗病例122例,观察患者上消化道出血后2周后血氨、肝功能、临床症状等指标。结果:上消化道出血后早期预防性应用门冬氨酸鸟氨酸治疗患者出现肝性脑病只有3例,占到2.3%(3/128);早期未给予预防性应用门冬氨酸鸟氨酸治疗患者出现肝性脑病有27例,占到22%(27/122);差异具有统计学意义(p<0.05)。结论:门冬氨酸鸟氨酸在预防肝硬化合并上消化道出血所诱发肝性脑病方面具有显著疗效,降低血氨水平,同时改善肝功能,减轻了患者的临床症状,控制病情进展。
Objective: To observe the clinical efficacy of ornithine ornithine in preventing hepatic encephalopathy induced by cirrhosis combined with upper gastrointestinal bleeding. Methods: A total of 250 patients with cirrhosis and upper gastrointestinal hemorrhage admitted to our hospital from 2009 to 2014 were enrolled. Of them, 128 cases were prophylactic use of aspartate ornithine after upper gastrointestinal bleeding in early stage, Ornithine ornithine given asymptomatic cases in 122 cases, observation of patients with upper gastrointestinal bleeding after 2 weeks of blood ammonia, liver function, clinical symptoms and other indicators. Results: Only 3 cases of hepatic encephalopathy occurred in prophylactic aspartate ornithine treatment after upper gastrointestinal bleeding, accounting for 2.3% (3/128). No prophylactic application of ornithine aspartate Acid therapy in patients with hepatic encephalopathy in 27 cases, accounting for 22% (27/122); the difference was statistically significant (p <0.05). CONCLUSION: Aspartate ornithine has a significant effect in preventing hepatic encephalopathy induced by cirrhosis and upper gastrointestinal hemorrhage, reducing blood ammonia level, improving liver function, relieving clinical symptoms and controlling disease progression.