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目的:研究种植体表面化学活化处理对种植体周围骨缺损愈合的影响。方法:采用6只成年Beagle犬,拔除下颌双侧前磨牙和第一磨牙3个月后行种植体植入术,在下颌第三前磨牙(P3)和第一磨牙(M1)部位常规制备直径2.8mm、深10mm的孔洞,其冠方5mm区域进一步扩孔制备成直径5.3mm的种植窝。每侧下颌骨植入直径3.3mm、长10mm的modSLA(化学活化大颗粒喷砂酸蚀)和SLA(大颗粒喷砂酸蚀)种植体各1颗,形成种植体冠方深5mm、宽1mm的环形骨缺损。双侧共植入4颗种植体,采用非埋入式愈合方式。术后2周、4周和8周时收获含种植体的骨组织标本,制成切片后,经苦味酸品红染色,检测骨结合率(BIC%)、新骨填充率(NBF%)以及新骨与种植体接触的最冠方水平至缺损底部的距离(B-D)。应用SPSS13.0软件包对数据进行分析。结果:观察期内无种植体松动脱落。3个时间段内,2组种植体周围的骨缺损区域皆有新骨生成,新骨形成始于缺损区的根方和侧方骨壁。2周和4周时,modSLA种植体的BIC%、NBF%和B-D值显著高于SLA种植体的相应指标值(P<0.05);8周时,2组之间无显著差异(P>0.05)。结论:化学活化表面处理方式有利于促进种植体周围骨缺损的早期骨愈合。
Objective: To study the effect of implant surface chemical activation treatment on the healing of bone defects around implants. METHODS: Six adult Beagle dogs were used to implant the mandibular premolar and first molars 3 months after mandibular extraction. Conventional mandibular third premolar (P3) and first molars (M1) 2.8mm, 10mm deep hole, the crown square 5mm area further reaming prepared into 5.3mm diameter planting nest. Each mandible was implanted with modSLA (chemically activated large particle sandblasting) and SLA (large particle sandblasting) implants with a diameter of 3.3 mm and a length of 10 mm, respectively, to form a dental implant with a depth of 5 mm and a width of 1 mm The annular defect. A total of four implants implanted on both sides, using non-embedded healing. Bone tissue samples were harvested at 2, 4 and 8 weeks postoperatively. Slides were harvested and stained with picric acid for detecting bone incorporation (BIC%), new bone filling (NBF%) and The distance between the most coronal level at which the new bone contacts the implant and the bottom of the defect (BD). SPSS13.0 software package for data analysis. Results: No implant loosened during the observation period. During 3 time periods, new bone was formed in the bone defect area around the two groups of implants. The new bone formation started from the root side and the lateral bone wall of the defect area. At 2 weeks and 4 weeks, the BIC%, NBF% and BD values of modSLA implants were significantly higher than those of SLA implants (P <0.05); there was no significant difference between the two groups at 8 weeks (P> 0.05 ). CONCLUSIONS: Chemically activated surface treatment promotes early bone healing of bone defects around implants.