目的:探讨高原出血坏死性胰腺炎猝死者的临床病理改变。方法:对误诊病例进行尸检,对全身系统脏器做病理组织观察。结果:死者表现全身多脏器损害,胰腺表现为不同程度的出血及坏死;胰腺外脏器表现为淤血、水肿,其中以肺水肿最为明显。结论:低容量休克、急性肺水肿、脑水肿、急性心力衰竭是猝死的重要原因。高原缺氧对促进胰腺组织坏死有一定的作用。 Objective: To investigate the clinicopathological changes of sudden death in high altitude hemorrhagic necrotizing pancreatitis. Methods: The autopsy was performed on the misdiagnosed cases and the pathological tissues of the whole body were observed. Results: The dead showed multiple organ damage, the pancreas showed varying degrees of bleeding and necrosis; external organs of the pancreas showed congestion, edema, of which the most obvious pulmonary edema. Conclusion: Low-volume shock, acute pulmonary edema, cerebral edema and acute heart failure are the important causes of sudden death. High altitude hypoxia can promote pancreatic tissue necrosis have a certain role.