在不同温度条件下利用微量热法测定了大肠杆菌以及大肠杆菌在６种Ｓｃｈｉｆ碱药物抑制下的生长热谱，找出了该细菌生长的最佳生长温度，获得了该细菌在不同温度条件及抑制情况下生长代谢的速率常数，并借助化学反应中分子碰撞理论计算了该细菌生长的生长活化能，在此基础上借用化学反应速率的活化络合物理论模型对大肠杆菌生长代谢的生化反应进行了热力学分析 The thermophilic spectra of Escherichia coli and Escherichia coli under the inhibition of six kinds of Schiff base drugs were determined by microcalorimetry under different temperature conditions and the optimal growth temperature of the bacteria was determined. Inhibition of growth and metabolic rate constants, and with the help of molecular collision theory of chemical reactions to calculate the growth of the bacteria growth activation energy, on this basis, the chemical reaction rate activation complex theoretical model of growth and metabolism of E. coli biochemical reactions Thermodynamic analysis was performed