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目的对比分析枸橼酸咖啡因与氨茶碱治疗早产儿原发性呼吸暂停的临床疗效和安全性。方法 122例早产儿原发性呼吸暂停患儿,随机分为观察组(给予枸橼酸咖啡因治疗)和对照组(给予氨茶碱治疗),各61例。比较两组的治疗效果和不良反应发生情况。结果观察组用药后3 d内呼吸暂停发生次数(12.82±2.87)次少于对照组的(14.21±2.66)次,用药时间(14.41±3.85)d短于对照组的(17.12±4.61)d(P<0.05)。观察组消化功能紊乱、高血糖发生率(8.2%、4.9%)低于对照组(21.3%、18.0%)(P<0.05)。结论枸橼酸咖啡因治疗早产儿原发性呼吸暂停,疗效优于氨茶碱,不良反应发生率更低。
Objective To compare the clinical efficacy and safety of citrate caffeine and aminophylline in the treatment of premature infants with primary apnea. Methods 122 cases of premature infants with primary apnea were randomly divided into observation group (given citrate caffeine treatment) and control group (given aminophylline treatment), each of 61 cases. Compare the two groups of treatment and adverse reactions. Results The number of apnea episodes (12.82 ± 2.87) in observation group within 3 days was less than that in control group (14.21 ± 2.66) and medication duration (14.41 ± 3.85) d was shorter than that in control group (17.12 ± 4.61) d P <0.05). In the observation group, the digestive dysfunction, the incidence of hyperglycemia (8.2%, 4.9%) were lower than those in the control group (21.3%, 18.0%) (P <0.05). Conclusions Citrate caffeine is superior to aminophylline in the treatment of primary apnea in preterm infants with a lower incidence of adverse reactions.