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目的研究新疆阿魏Ferula sinkiangensis种子的化学成分。方法利用不同的色谱分离纯化手段,根据化合物的理化常数和光谱数据进行结构鉴定。结果从新疆阿魏种子90%乙醇提取液中分离得到32个化合物,分别鉴定为丁二酸(1)、两型曲霉醌A(2)、β-谷甾醇(3)、豆甾醇-3-O-葡萄糖苷(4)、1-(3-乙基苯基)-1,2-乙二醇(5)、松脂素(6)、(7,8-cis-8,8′-trans)-2′,4′-二羟基-3,5-二甲氧基-落叶松脂素(7)、开环异落叶松脂醇(8)、正二十六醇(9)、异槲皮素苷(10)、槲皮素(11)、阿魏酸(12)、豆甾醇(13)、木犀草素-7-O-β-D-葡萄糖醛酸苷(14)、(R)-2′-hydroxy-N-[(2S,3S,4R)-1,3,4-trihydroxyhexacosan-2-yl]nonadanamide(15)、macrathoinF(16)、1,5-二-O-咖啡酰奎尼酸(17)、牛蒡苷(18)、parvifoliols G(19)、5-羟甲基糠醛(20)、胡萝卜苷(21)、香草酸(22)、蔗糖(23)、芦丁(24)、neoarctin A(25)、绿原酸甲酯(26)、5-O-咖啡酰基奎宁酸(27)、尿嘧啶核苷(28)、次黄嘌呤核苷(29)、7-羟基香豆素(30)、绿原酸(31)、咖啡酸(32)。结论化合物2、5~11、14~20、22、24~29、31、32为首次从该属植物中分离得到。
Aim To study the chemical constituents of Ferula sinkiangensis in Xinjiang Uygur Autonomous Region. Methods Different chromatographic separation and purification methods were used to identify the structures of compounds based on their physicochemical constants and spectral data. Results Thirty-two compounds were isolated from 90% ethanol extract of Asiaticus Seeds and identified as succinic acid (1), Aspergillus flavone A (2), β-sitosterol (3) (4), 1- (3-ethylphenyl) -1,2-ethanediol (5), phorbol ester (6), (7,8-cis-8,8’-trans) -2 ’, 4’-dihydroxy-3,5-dimethoxy-larchinone (7), enkephalinol (8), n-hexacosanol (9), isoquercetin (10), quercetin (11), ferulic acid (12), stigmasterol (13), luteolin-7-O-β-D-glucuronide (14) -hydroxy-N - [(2S, 3S, 4R) -1,3,4-trihydroxyhexacosan-2-yl] nonadanamide (15), macrathoin F 15, parvifoliols G (19), 5-hydroxymethylfurfural (20), daucosterol (21), vanillic acid (22), sucrose (23), rutin (24), neoarctin A (25) Methyl chloroformate (26) 5-O-caffeoylquinic acid (27) Uridine (28) Inosine (29) 7-hydroxycoumarin 30), chlorogenic acid (31), caffeic acid (32). Conclusion Compounds 2, 5 ~ 11, 14 ~ 20, 22, 24 ~ 29, 31, 32 were isolated from this genus for the first time.