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目前已有资料证明,细胞内寄生虫对宿主具有免疫抑制作用,且能促发其他感染,或增加这些感染的致病性。Huldt等的实验结果显示鼠类的弓浆虫(Toxoplasma gondii)感染对胸腺的解剖学及其功能都有影响,并认为寄生虫以某种方式干扰了胸腺细胞的分化及移行。Huldt和Waller发现弓浆虫和Moloney病毒双重感染的小鼠可发生急性和致死性的疾病过程,而微胞子虫(Nosemacuniculi)是鼠类的一种普通寄生虫,在正常情况下并不引起临床症状,故认为双重感染导致急性致死性过程的发生与这二种感染所
It has been documented that intracellular parasites have immunosuppressive effects on the host and can elicit other infections or increase the pathogenicity of these infections. Experimental results by Huldt et al. Showed that the murine Toxoplasma gondii infection affects both the anatomy and function of the thymus and suggests that the parasite interferes with the thymocyte differentiation and migration in some way. Huldt and Waller found acute and lethal disease processes occur in mice infected with Toxoplasma gondii and Moloney virus, while Nosemacuniculi is a common parasite of the mouse that does not normally cause clinical Symptoms, so that double infection led to the occurrence of acute fatal process and these two infections