作者曾证明青蛙(Rana tempor0ria)对亚硝基化合物的致癌作用具有高度敏感性。本文研究二甲基亚硝胺致癌作用与剂量的相关。实验用1～1.5周龄的285只雌性和雄性青蛙(Rana temproria)置于6～10℃玻璃容器内(每个容器5只青蛙,每个青蛙按500 ml水计算),每天换水,水内含,其浓度为实验确定的毒性LD_(50～30)的1/30～2/3。第1组65只青蛙接受剂量为1ppm,第2组110只剂量为5 ppm,第3组62只和第4组48只的剂量分别为10和20 ppm。染毒时间为动物的整个生存期;第 The authors have demonstrated that Rana tempor0ria is highly sensitive to the carcinogenic effects of nitroso compounds. This article studies the carcinogenic effect of dimethylnitrosamine and its dose. Experiments A total of 285 female and male Rana temproria, aged from 1 to 1.5 weeks old, were placed in 6 to 10 ° C glass containers (5 frogs per container, each containing 500 ml of water), changing water daily, water Contained, the concentration of the experimentally determined toxicity LD_ (50 ~ 30) 1/30 ~ 2/3. The first group of 65 frogs received doses of 1 ppm, the second group of 110 doses of 5 ppm, the third group of 62 and fourth group of 48 doses of 10 and 20 ppm, respectively. Exposure time for the entire life of the animal;