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为了研究三唑安定(Triazolam)经舌下途径吸收入体内的药物动力学特性,8名健康男性志愿者(20~45岁)参加了本试验。试验设计采用随机交叉,每次试验无论舌下含服或口服法均为单次三唑安定片0.5mg,两种服法交叉进行,间隔至少一周。受试者于每次用药前禁食至少8小时,用药后再继续禁食3小时。在用药前及用药后15,30和45分钟及1,1.5,2,2.5,3,4,5,6,8,10,12,15,18,24小时各抽取静脉血一次,以测定血浆中三唑安定的浓度。
Eight healthy male volunteers (20-45 years old) participated in the study in order to study the pharmacokinetic properties of Triazolam absorbed into the body through the sublingual route. Experimental design using a random cross, each test regardless of sublingual or oral method are single triazophos 0.5mg, the two methods of cross, at least one week intervals. Subjects fasted for at least 8 hours prior to each administration and then fasted for another 3 hours after treatment. Venous blood was taken before and at 15, 30 and 45 minutes and at 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 12, 15, 18 and 24 hours after administration to determine plasma Midazolam stability of the concentration.