在南美洲,慢性锥虫病性心肌炎为猝死的常见病因。常见多种心电图异常,包括心室内及房室传导阻滞、窦房结功能不全、异常 Q 波及原发性 T 波改变。室性心律失常的病发率极高而治疗却很困难。本文报道以胺碘酮长程治疗慢性锥虫病性心肌炎患者的恶性室性心律失常,特别着重于剂量一效应间的相互关系、到达最大抗心律失常疗效的时间、停药 In South America, chronic trypanosomiasis myocarditis is a common cause of sudden death. A variety of common ECG abnormalities, including intraventricular and atrioventricular block, sinus node dysfunction, abnormal Q wave and primary T wave changes. The incidence of ventricular arrhythmias is extremely high and treatment is difficult. This article reports the long-term amiodarone treatment of patients with chronic trypanosomiasis with malignant ventricular arrhythmias, with particular emphasis on the relationship between dose-response, reaching the maximum anti-arrhythmic effect time, withdrawal