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可溶性环氧化合物水解酶(soluble epoxide hydrolase,sEH)是哺乳动物体内广泛存在的一种酶。sEH通过水解环氧二十碳三烯酸(epoxyeicosatrienoic acids,EETs)发挥作用。近来研究发现sEH与高血压、终末器官损伤、心肌肥厚及缺血/再灌注损伤关系密切,极有可能成为一种预防和治疗心血管疾病的新靶点。
Soluble epoxide hydrolase (sEH) is an enzyme widely found in mammals. sEH works by hydrolyzing epoxyeicosatrienoic acids (EETs). Recent studies have found that sEH and hypertension, end organ damage, cardiac hypertrophy and ischemia / reperfusion injury are closely linked, is likely to become a new target for the prevention and treatment of cardiovascular disease.