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长链非编码RNA(long noncoding RNAs,lncRNAs)是人类基因组中广泛转录的一类转录本长度超过200 nt的非编码RNA。越来越多研究表明,lncRNAs对生命活动及肿瘤发生起重要调控作用。lncRNAs的异常表达在多种人类肿瘤中发现,然而其功能及作用机制还有待于进一步研究。本文对lncRNAs的作用机制及其在人类肿瘤中的研究现状进行综述。
Long-length noncoding RNAs (lncRNAs) are a class of non-coding RNAs that are more than 200 nt in length transcribed extensively in the human genome. More and more studies have shown that lncRNAs play an important regulatory role in life activity and tumorigenesis. Abnormal expression of lncRNAs is found in many human tumors, however, its function and mechanism need to be further studied. This review summarizes the mechanism of action of lncRNAs and their research status in human tumors.